Thrust into an all-new adventure, a down-on-his-luck Captain Jack Sparrow feels the winds of ill fortune blow even stronger when deadly ghost sailors led by his old nemesis, the evil Captain Salazar, escape the Devil's Triangle. Jack's only hope for survival is to find the legendary Trident of Poseidon, but to find it, he must forge an uneasy alliance with a brilliant astronomer and a headstrong young British navy man.
Captain Jack Sparrow's checkered past catches up with him when he meets Angelica, a beautiful pirate Jack once loved and then left. Angelica forces him to accompany her to the Queen Anne's Revenge, the ship of the famous Blackbeard. Accompanied by a crew of zombies, the trio set sail to find the legendary Fountain of Youth. However, Jack's rival Barbossa is also searching for the source, as is a ship from Spain.
Will Turner and Elizabeth Swann join forces with Captain Barbossa to free Jack Sparrow from Davy Jones' locker. Meanwhile, the crew of the ghost ship Flying Dutchman wreaks havoc on the Seven Seas. The friends must navigate dangerous waters to take on the Chinese pirate Sao Feng, ultimately choosing sides in a battle where pirate lives hang in the balance.
When ghostly pirate Davy Jones comes to collect a blood debt, Captain Jack Sparrow must find a way to avoid his fate so his soul isn't forever damned. However, the cunning ghost manages to disrupt the wedding plans of Jack's friends, Will Turner and Elizabeth Swann.
Captain Jack Sparrow arrives at Port Royal in the Caribbean without a ship or crew. However, his timing is inopportune because later that night, the town is besieged by a pirate ship. The pirates kidnap the governor's daughter, Elizabeth, who is in possession of a valuable coin linked to a curse that has turned the pirates into the undead. A brave blacksmith in love with Elizabeth joins forces with Sparrow in the pursuit of pirates.