The wife and son of a Mexican drug lord embark on a vengeful quest to kill all those involved in his trial and imprisonment including Miami Detective Mike Lowrey. When Mike gets wounded, he teams up with partner Marcus Burnett and AMMO a special tactical squad to bring the culprits to justice. But the old-school, wisecracking cops must soon learn to get along with their new elite counterparts if they are to take down the vicious cartel that threatens their lives.
The drug ecstasy is flowing into Miami, and the police want it stopped. Police Detective Marcus Burnett and his partner, Mike Lowrey are just the men to do it. They track the drugs to a Cuban smuggler, Johnny Tapia who is also involved in a bloody war with Russian and Haitian mobsters. If that isn't bad enough, there's tension between the two cops because Lowrey is romantically involved with burnett's sister, Syd.
The detectives Mike Lowrey and Marcus Burnett blow a fuse when $100 million worth of heroin they recently confiscated is heisted from station headquarters. Suspecting it was an inside job, internal affairs gives them five days to track down the drugs before they shut down the narcotics division. Action meets farce when Marcus is compelled to masquerade as his partner in order to gain the trust of a call girl, a key witness in their investigation.