The Spengler family returns to the iconic New York City firehouse where the original Ghostbusters have taken ghost busting to the next level. When the discovery of an ancient artifact unleashes an evil force, Ghostbusters new and old must unite to protect their home and save the world from a second ice age.
Paranormal researcher Abby Yates and physicist Erin Gilbert are trying to prove that ghosts exist in modern society. When strange apparitions appear in Manhattan, Gilbert and Yates turn to engineer Jillian Holtzmann for help. Also joining the team is Patty Tolan, a lifelong New Yorker who knows the city inside and out. Armed with proton packs and plenty of attitude, the four women prepare for an epic battle as more than 1,000 mischievous ghouls descend on Times Square.
After saving New York City from a ghost attack, the Ghostbusters a team of spirit exterminators is disbanded for demolishing parts of the city during the battle. But when Ghostbuster Peter Venkman learns that spirits have taken an interest in his son, the men launch a rogue ghost chasing mission. The quest quickly goes awry, landing them in court. But when the ghosts turn on the judge, he issues an order allowing the Ghostbusters to get back to work.
A team of scientists lose their cushy positions at a university in New York City, they decide to become "Ghostbusters" to wage a high tech battle with the supernatural for money. They stumble upon a gateway to another dimension, a doorway that will release evil upon the city. The Ghostbusters must now save New York from complete destruction.